It's important to work closely with your doctor and to keep track of how you are feeling and doing. You may feel side effects before you start feeling better. If you are not feeling the pain relief you expect, there may be things your doctor can do to help.

Your doctor can adjust your dose to help you get the most from treatment.


Dosage strengths of LYRICADosage strengths of LYRICA


  • Start with 75 mg
    2 times a day (For a total of 150 mg/day)
  • Dosage may be increased based on efficacy & tolerability
  • Up to 300 mg
    2 times a day (For a total of 600 mg/day)

Work with your doctor to figure out the best dosage for you. The recommended total starting dosage is 150 mg per day. The dose may be increased to 300 mg per day within 1 week, based on efficacy and tolerability. Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg per day, and who are able to tolerate LYRICA, may be treated with up to 600 mg per day. Your doctor may continue to make adjustments according to your needs. If you have problems with kidney function, your doctor may prescribe a lower dose of LYRICA.


Across all clinical studies, side effects were generally mild to moderate. Side effects can vary from person to person, so make sure to talk with your doctor about any side effects you may be experiencing.
  • 1–2 weeks
  • 3–4 weeks
  • 5 weeks +
1–2 weeks

In clinical trials, some patients started feeling less spinal cord injury nerve pain as early as the first week of treatment. For others it took longer and individual results may vary.

It’s possible you may begin to feel side effects within the first week. The 2 most common side effects of LYRICA are dizziness and sleepiness. Across all clinical studies, dizziness occurred in 30% of LYRICA patients, compared with 8% of patients taking a placebo and, on average, lasted about 1.5 weeks. For some people, this went away over time. For others, these side effects lasted throughout the course of the studies.

If you do experience side effects, your doctor can adjust your dose or provide recommendations to help.

After the first week of treatment, your doctor may increase your dose based on the efficacy of LYRICA and how well you may tolerate it. This is a normal step when taking LYRICA. Of course, your doctor will make adjustments based on how you’re feeling in regard to both pain relief and side effects. It’s not recommended that you take more than 300 to 600 mg of LYRICA per day for spinal cord injury nerve pain.

3–4 weeks

After the first few weeks of taking LYRICA, follow up with your doctor and start discussing your complete treatment plan, and get any refills you may need.

This is the right time for you to discuss with your doctor how you are doing and any side effects you may feel. Everyone is unique, and may respond to LYRICA differently.

LYRICA is available in multiple strengths. Your doctor can adjust your dose to help you get the most from treatment.

5 weeks +

After 1 to 2 months of taking LYRICA, be sure to continue to keep your doctor informed. This will enable you both to decide the best course of action to help you get the most from your treatment.

Sleepiness occurred in 23% of LYRICA patients, compared with 8% of patients taking a placebo and, on average, lasted over 10 weeks. For some people, this went away over time. For others, this side effect lasted throughout the course of the studies.

Taking to Your Doctor


Get helpful tips on how to talk to your doctor about spinal cord injury nerve pain.

LYRICA® (pregabalin) Capsules CV co-pay savings card


Eligible Patients may pay as little as $4 per Rx with the Co-Pay Savings Card.


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LYRICA is not for everyone. LYRICA may cause serious, even life-threatening, allergic reactions. Stop taking LYRICA and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck, if you have any trouble breathing, or have a rash, hives, or blisters.

Drugs used to treat seizures increase the risk of suicidal thoughts or behavior. LYRICA may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients, family members, or caregivers should call the doctor right away if they notice suicidal thoughts or actions, thoughts of self-harm, or any unusual changes in mood or behavior. These changes may include new or worsening depression, anxiety, restlessness, trouble sleeping, panic attacks, anger, irritability, agitation, aggression, dangerous impulses or violence, or extreme increases in activity or talking. If you have suicidal thoughts or actions, do not stop LYRICA without first talking to your doctor.

Serious breathing problems can occur when LYRICA is taken with other medicines that can cause severe sleepiness or decreased awareness, or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting LYRICA or when the dose is increased. Get help right away if breathing problems occur.

LYRICA may cause swelling of your hands, legs, and feet, which can be serious for people with heart problems. LYRICA may cause dizziness and sleepiness. You should not drive or work with machines until you know how LYRICA affects you. Also, tell your doctor right away about muscle pain or problems along with feeling sick and feverish, or any changes in your eyesight, including blurry vision or if you have any kidney problems or get dialysis.

Tell your doctor immediately if you are taking opioid painkillers (such as oxycodone), or medicines for anxiety (such as lorazepam) or insomnia (such as zolpidem). You may have a higher chance for dizziness, sleepiness or serious breathing problems if these medicines are taken with LYRICA. Taking LYRICA with opioid pain medicines may lead to death.

Some of the most common side effects of LYRICA are dizziness, blurry vision, weight gain, sleepiness, trouble concentrating, swelling of your hands and feet, dry mouth, and feeling “high.” If you have diabetes, tell your doctor about any skin sores.

You may have a higher chance for swelling and hives if you are also taking angiotensin-converting enzyme (ACE) inhibitors, so tell your doctor if you are taking these medications. You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking certain diabetes medicines. Do not drink alcohol while on LYRICA. You may have a higher chance for dizziness and sleepiness if you take LYRICA with alcohol, narcotic pain medicines, or medicines for anxiety.

Before you start LYRICA, tell your doctor if you are planning to father a child, if you are pregnant, or plan to become pregnant. Breastfeeding is not recommended while taking LYRICA. If you have had a drug or alcohol problem, you may be more likely to misuse LYRICA.

In studies, a specific type of blood vessel tumor was seen in mice. The meaning of these findings in humans is not known.

Do not stop taking LYRICA without talking to your doctor. If you stop suddenly, you may have headaches, nausea, diarrhea, trouble sleeping, increased sweating, or you may feel anxious. If you have epilepsy, you may have seizures more often.

LYRICA is available in doses ranging from 25 mg to 300 mg and as a 20 mg/mL oral solution.


LYRICA is indicated to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles in adult patients. LYRICA is also indicated to treat partial-onset seizures in patients 1 month of age and older with epilepsy who take 1 or more other drugs for seizures.

Please see full Prescribing Information and Medication Guide.