PARTIAL ONSET SEIZURES ARE DIFFERENT

Seizures are the result of sudden, abnormal electrical activity in the brain. A sudden increase in activity in a small part of the brain can cause a partial seizure. Medicines, high fevers, and head injuries can all cause a seizure. But many people with epilepsy have no clear cause to point to.

There are two kinds of seizures: generalized seizures that take place across both sides of the brain and partial seizures that are localized in one part of the brain. And there are two basic types of partial seizures: simple and complex.

During simple partial seizures, a person:

  • Stays alert
  • Can answer questions and follow commands
  • Can recall what happened during the seizure

During complex partial seizures, a person:

  • Loses or has a change in consciousness
  • May not be able to answer questions or follow commands
  • Often cannot recall what happened during part or all of the seizure

LYRICA IS FDA APPROVED AS AN ADD-ON TREATMENT FOR PARTIAL ONSET SEIZURES

IN CLINICAL STUDIES, IT WAS SHOWN THAT FOR SOME ADULT PATIENTS WITH EPILEPSY:

LYRICA can provide significant relief as an add-on therapy for partial onset seizures*

For some adults with epilepsy in clinical studies, LYRICA was proven as an add-on therapy to significantly reduce the frequency of partial onset seizures compared to a placebo.*

*Individual results may vary.

HOW DOES LYRICA WORK?

Neuron

LYRICA is believed to calm overactive nerves

For someone with epilepsy, calming overactive nerve cells can help control seizures, when combined with other therapies. It is unknown exactly how LYRICA works in the body. Animal studies suggest that LYRICA reduces “extra” electrical signals sent out by overactive nerves. The implication of these studies in humans is not known.

Types of pills

LYRICA can be taken with other medications

You most likely are taking at least 1 other medication to help manage your partial onset seizures. So it’s good to know that LYRICA has a low potential for drug interaction. But it does interact with some medicines.

Tell your doctor about all the medicines, vitamins, or herbal supplements you take, especially medicines that make you sleepy or if you take:

  • An ACE inhibitor, used to treat many conditions, such as high blood pressure
  • Avandia (rosiglitazone), Avandamet (contains rosiglitazone and metformin), or Actos (pioglitazone) for diabetes
  • Any opioid pain medicine (such as oxycodone), or medicines for anxiety (such as lorazepam) or insomnia (such as zolpidem).

WORK WITH YOUR DOCTOR TO REDUCE PARTIAL ONSET SEIZURES

Many people who take 1 or even 2 or more medicines still have seizures. Your doctor may suggest an add-on treatment, like LYRICA, for relief.

START THE CONVERSATION

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IMPORTANT SAFETY INFORMATION

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LYRICA is not for everyone. LYRICA may cause serious, even life-threatening, allergic reactions. Stop taking LYRICA and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck, if you have any trouble breathing, or have a rash, hives, or blisters.

Drugs used to treat seizures increase the risk of suicidal thoughts or behavior. LYRICA may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients, family members, or caregivers should call the doctor right away if they notice suicidal thoughts or actions, thoughts of self-harm, or any unusual changes in mood or behavior. These changes may include new or worsening depression, anxiety, restlessness, trouble sleeping, panic attacks, anger, irritability, agitation, aggression, dangerous impulses or violence, or extreme increases in activity or talking. If you have suicidal thoughts or actions, do not stop LYRICA without first talking to your doctor.

Serious breathing problems can occur when LYRICA is taken with other medicines that can cause severe sleepiness or decreased awareness, or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting LYRICA or when the dose is increased. Get help right away if breathing problems occur.

LYRICA may cause swelling of your hands, legs, and feet, which can be serious for people with heart problems. LYRICA may cause dizziness and sleepiness. You should not drive or work with machines until you know how LYRICA affects you. Also, tell your doctor right away about muscle pain or problems along with feeling sick and feverish, or any changes in your eyesight, including blurry vision or if you have any kidney problems or get dialysis.

Tell your doctor immediately if you are taking opioid painkillers (such as oxycodone), or medicines for anxiety (such as lorazepam) or insomnia (such as zolpidem). You may have a higher chance for dizziness, sleepiness or serious breathing problems if these medicines are taken with LYRICA. Taking LYRICA with opioid pain medicines may lead to death.

Some of the most common side effects of LYRICA are dizziness, blurry vision, weight gain, sleepiness, trouble concentrating, swelling of your hands and feet, dry mouth, and feeling “high.” If you have diabetes, tell your doctor about any skin sores.

You may have a higher chance for swelling and hives if you are also taking angiotensin-converting enzyme (ACE) inhibitors, so tell your doctor if you are taking these medications. You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking certain diabetes medicines. Do not drink alcohol while on LYRICA. You may have a higher chance for dizziness and sleepiness if you take LYRICA with alcohol, narcotic pain medicines, or medicines for anxiety.

Before you start LYRICA, tell your doctor if you are planning to father a child, if you are pregnant, or plan to become pregnant. Breastfeeding is not recommended while taking LYRICA. If you have had a drug or alcohol problem, you may be more likely to misuse LYRICA.

In studies, a specific type of blood vessel tumor was seen in mice. The meaning of these findings in humans is not known.

Do not stop taking LYRICA without talking to your doctor. If you stop suddenly, you may have headaches, nausea, diarrhea, trouble sleeping, increased sweating, or you may feel anxious. If you have epilepsy, you may have seizures more often.

LYRICA is available in doses ranging from 25 mg to 300 mg and as a 20 mg/mL oral solution.

INDICATIONS

LYRICA is indicated to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles in adult patients. LYRICA is also indicated to treat partial-onset seizures in patients 1 month of age and older with epilepsy who take 1 or more other drugs for seizures.

Please see full Prescribing Information and Medication Guide.