LYRICA and LYRICA CR are not for everyone.
LYRICA and LYRICA CR may cause serious, even life-threatening, allergic reactions. Stop taking LYRICA or LYRICA CR and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck, if you have any trouble breathing, or have a rash, hives, blisters, or skin redness.
LYRICA and LYRICA CR may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients, family members, or caregivers should call the doctor right away if they notice suicidal thoughts or actions, thoughts of self-harm, or any unusual changes in mood or behavior. These changes may include new or worsening depression, anxiety, restlessness, trouble sleeping, panic attacks, anger, irritability, agitation, aggression, dangerous impulses or violence, or extreme increases in activity or talking. If you have suicidal thoughts or actions, do not stop LYRICA or LYRICA CR without first talking to your doctor.
Serious breathing problems can occur when LYRICA or LYRICA CR is taken with other medicines that can cause severe sleepiness or decreased awareness or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting LYRICA or LYRICA CR or when the dose is increased. Get help right away if breathing problems occur.
LYRICA and LYRICA CR may cause swelling of your hands, legs, and feet, which can be serious for people with heart problems.
LYRICA and LYRICA CR may cause dizziness and sleepiness. You should not drive or work with machines until you know how LYRICA or LYRICA CR affects you. Also, tell your doctor right away about muscle pain or problems along with feeling sick and feverish or any changes in your eyesight, including blurry vision or if you have any kidney problems or get dialysis.
Tell your doctor immediately if you are taking opioid painkillers. Taking LYRICA in combination with these medications may reduce central nervous system activity that could lead to death.
Tell your doctor immediately if you are taking any opioid pain medicine (such as oxycodone), tranquilizers or medicines for anxiety (such as lorazepam), or insomnia (such as zolpidem). You may have a higher chance for dizziness and sleepiness or serious breathing problems if these medicines are taken with LYRICA or LYRICA CR. Taking LYRICA or LYRICA CR with opioid pain medicines may lead to death.
Some of the most common side effects of LYRICA CR are dizziness, blurry vision, weight gain, sleepiness, tiredness, swelling of hands and feet, dry mouth, and nausea.
If you have diabetes, tell your doctor about any sores or skin problems.
You may have a higher chance for swelling and hives if you are also taking angiotensin-converting enzyme (ACE) inhibitors, so tell your doctor if you are taking these medications. You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking Avandia (rosiglitazone), Avandamet (contains rosiglitazone and metformin), or Actos (pioglitazone). Do not drink alcohol while on LYRICA or LYRICA CR. You may have a higher chance for dizziness and sleepiness if you take LYRICA or LYRICA CR with alcohol, narcotic pain medicines, or medicines for anxiety.
Before you start LYRICA or LYRICA CR, tell your doctor if you are planning to father a child, if you are pregnant, or plan to become pregnant. Breastfeeding is not recommended while taking LYRICA or LYRICA CR. If you have had a drug or alcohol problem, you may be more likely to misuse LYRICA or LYRICA CR.
In studies, a specific type of blood vessel tumor was seen in mice. The meaning of these findings in humans is not known.
Do not stop taking LYRICA or LYRICA CR without talking to your doctor. If you stop suddenly, you may have headaches, nausea, diarrhea, trouble sleeping, increased sweating, or you may feel anxious. If you have epilepsy, you may have seizures more often.
LYRICA is available in doses ranging from 25 mg to 300 mg and as a 20 mg/mL oral solution.
LYRICA CR is available in doses ranging from 82.5 mg to 330 mg.
LYRICA is indicated to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles in adult patients. LYRICA is also indicated to treat partial-onset seizures in patients 1 month of age and older with epilepsy who take 1 or more other drugs for seizures.
LYRICA CR is indicated to treat pain from damaged nerves (neuropathic pain) that happens with diabetes or that follows healing of shingles.
It is not known if LYRICA CR is safe and effective in children.
It is not known if LYRICA CR is effective when used for the treatment of fibromyalgia or when taken with other seizure medicines for adults with partial-onset seizures.
Please see full LYRICA Prescribing Information and Medication Guide.
Please see full LYRICA CR Prescribing Information and Medication Guide.