How is LYRICA believed to work?

The shingles virus travels to your skin by following your nerves. Along the way, the virus damages these nerves. These damaged nerves are what cause pain after shingles. LYRICA (pregabalin) is believed to work on damaged or overactive nerves that are thought to cause nerve pain. Although it is unknown exactly how LYRICA works in the body, animal studies suggest that LYRICA reduces “extra” electrical signals sent out by these damaged nerves. The implication of these studies in humans is not known.

Pain After Shingles