LYRICA CR IS AVAILABLE IN 3 DOSAGE STRENGTHS

LYRICA CR 82.5 mg, 165 mg, 330 mg

How is LYRICA CR different? LYRICA® (pregabalin) Capsules CV logo LYRICA® CR (pregabalin) Extended Release Tablets logo

How often do you take it?*

Diabetic Nerve Pain: 3 times a day

Pain After Shingles: 2–3 times a day

Once a day

Recommended starting dose (daily total)

Diabetic Nerve Pain: 150 mg/day

Pain After Shingles: 150 mg/day

Diabetic Nerve Pain: 165 mg/day

Pain After Shingles: 165 mg/day

Recommended ongoing dose (daily total)

Diabetic Nerve Pain: Up to 300 mg/day

Pain After Shingles: 150-600 mg/day

Diabetic Nerve Pain: 330 mg/day††

Pain After Shingles: 330-660 mg/day

If you have kidney problems or get kidney dialysis, your doctor may adjust your dosage of LYRICA or LYRICA CR.

*LYRICA/LYRICA CR is available in multiple strengths. Your doctor can adjust your dose to help you get the most from treatment.

300 mg/day is the maximum recommended LYRICA dose for diabetic nerve pain.

††330 mg/day is the maximum recommended LYRICA CR dose for diabetic nerve pain.

Patients who do not experience sufficient pain relief following 2 to 4 weeks of treatment with 300 mg per day, and who are able to tolerate LYRICA, may be treated with up to 600 mg/day.

Patients who do not experience sufficient pain relief with 330 mg/day after 2 to 4 weeks of treatment and who are able to tolerate LYRICA CR may be titrated up to 660 mg/day.

WHY WOULD MY DOSAGE CHANGE?

Increasing or decreasing your dose may help improve results.

Your doctor can adjust your dose to help you get the most from treatment. So it’s important to discuss your progress and any side effects you may feel with your doctor, especially in the first few weeks. Do not change your dose without talking to your doctor.

Be sure to talk to your doctor if stopping treatment.

Talking to your doctor is very important if you choose to stop treatment. Do not stop taking LYRICA CR on your own. Your doctor can help you minimize potential side effects when stopping LYRICA CR.

WHAT ARE THE COMMON SIDE EFFECTS OF LYRICA CR?

The 2 most common side effects of LYRICA CR were dizziness and sleepiness. For some patients, these side effects went away over time. For others, these lasted throughout their treatment.

In controlled LYRICA CR trials of up to 19 weeks, 4% of patients taking LYRICA CR gained weight, compared with 2% of patients taking a placebo.

TALKING TO YOUR DOCTOR

Get helpful tips on how to talk to your doctor about diabetic nerve pain.

LYRICA® (pregabalin) Capsules CV co-pay savings card

SAVE ON LYRICA

Eligible Patients may pay as little as $4 per Rx with the Co-Pay Savings Card.

RxPathways

RxPathways

IMPORTANT SAFETY INFORMATION

Full size

LYRICA is not for everyone. LYRICA may cause serious, even life-threatening, allergic reactions. Stop taking LYRICA and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck, if you have any trouble breathing, or have a rash, hives, or blisters.

Drugs used to treat seizures increase the risk of suicidal thoughts or behavior. LYRICA may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients, family members, or caregivers should call the doctor right away if they notice suicidal thoughts or actions, thoughts of self-harm, or any unusual changes in mood or behavior. These changes may include new or worsening depression, anxiety, restlessness, trouble sleeping, panic attacks, anger, irritability, agitation, aggression, dangerous impulses or violence, or extreme increases in activity or talking. If you have suicidal thoughts or actions, do not stop LYRICA without first talking to your doctor.

Serious breathing problems can occur when LYRICA is taken with other medicines that can cause severe sleepiness or decreased awareness, or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting LYRICA or when the dose is increased. Get help right away if breathing problems occur.

LYRICA may cause swelling of your hands, legs, and feet, which can be serious for people with heart problems. LYRICA may cause dizziness and sleepiness. You should not drive or work with machines until you know how LYRICA affects you. Also, tell your doctor right away about muscle pain or problems along with feeling sick and feverish, or any changes in your eyesight, including blurry vision or if you have any kidney problems or get dialysis.

Tell your doctor immediately if you are taking opioid painkillers (such as oxycodone), or medicines for anxiety (such as lorazepam) or insomnia (such as zolpidem). You may have a higher chance for dizziness, sleepiness or serious breathing problems if these medicines are taken with LYRICA. Taking LYRICA with opioid pain medicines may lead to death.

Some of the most common side effects of LYRICA are dizziness, blurry vision, weight gain, sleepiness, trouble concentrating, swelling of your hands and feet, dry mouth, and feeling “high.” If you have diabetes, tell your doctor about any skin sores.

You may have a higher chance for swelling and hives if you are also taking angiotensin-converting enzyme (ACE) inhibitors, so tell your doctor if you are taking these medications. You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking certain diabetes medicines. Do not drink alcohol while on LYRICA. You may have a higher chance for dizziness and sleepiness if you take LYRICA with alcohol, narcotic pain medicines, or medicines for anxiety.

Before you start LYRICA, tell your doctor if you are planning to father a child, if you are pregnant, or plan to become pregnant. Breastfeeding is not recommended while taking LYRICA. If you have had a drug or alcohol problem, you may be more likely to misuse LYRICA.

In studies, a specific type of blood vessel tumor was seen in mice. The meaning of these findings in humans is not known.

Do not stop taking LYRICA without talking to your doctor. If you stop suddenly, you may have headaches, nausea, diarrhea, trouble sleeping, increased sweating, or you may feel anxious. If you have epilepsy, you may have seizures more often.

LYRICA is available in doses ranging from 25 mg to 300 mg and as a 20 mg/mL oral solution.

INDICATIONS

LYRICA is indicated to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain, and pain after shingles in adult patients. LYRICA is also indicated to treat partial-onset seizures in patients 1 month of age and older with epilepsy who take 1 or more other drugs for seizures.

Please see full Prescribing Information and Medication Guide.