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For some patients, LYRICA can help relieve moderate to even severe diabetic nerve pain.

Diabetic Nerve Pain Relief | LYRICA® (pregabalin) CV Safety Info

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Helping Relieve Diabetic Nerve Pain with LYRICA*

Diabetic nerve pain is a form of nerve pain

Diabetic nerve pain is different than pain you may experience from a headache, a sprained ankle or arthritis. That's because the shooting, burning, pins and needles pain of diabetic nerve pain is the result of damaged nerves.

LYRICA is approved for the management of diabetic nerve pain

LYRICA is FDA-approved to be taken every day for the management of diabetic nerve pain. Over-the-counter pain relief pills are not approved by the FDA for the management of diabetic nerve pain. LYRICA is not an antidepressant or a narcotic. However, those who have had drug or alcohol problems may be more likely to misuse LYRICA. There is no generic version of LYRICA.

Shooting, burning, pins and needles pain?
Don’t ignore your pain. For some patients, LYRICA can provide significant relief from diabetic nerve pain, so they feel better.*

*Individual results may vary.

For some patients, LYRICA can provide significant diabetic nerve pain relief

LYRICA can help relieve diabetic nerve pain. Some patients in a 5-week clinical study who took LYRICA had significant pain relief and felt better than those patients taking a placebo. In diabetic nerve pain clinical studies, some patients felt less pain in as early as 1 week.*

Across all clinical studies, side effects were generally mild to moderate. The 2 most common side effects while taking LYRICA were dizziness and sleepiness. For some people, they went away over time. For others, they lasted throughout the course of the studies.

Other common side effects in these clinical studies included dry mouth, swelling of the hands and feet, blurred vision, weight gain, trouble concentrating, and feeling “high.”

Learn more about how to take LYRICA and the potential side effects of LYRICA.

*Individual results may vary.

How LYRICA is believed to work on damaged nerves

People with diabetes have high blood sugar levels. Having high blood sugar over time or fluctuations in blood sugar damages nerves. In some people, this damage causes a distinct type of pain—diabetic nerve pain. LYRICA is believed to work on these damaged nerves.

It is unknown exactly how LYRICA works in the body. Animal studies suggest that LYRICA reduces “extra” electrical signals sent out by these damaged nerves. The implication of these studies in humans is not known.

LYRICA can be taken with other medicines

LYRICA has a low potential for drug interaction, but does interact with some medicines. Tell your doctor about all the medicines, vitamins or herbal supplements you take, especially medicines that make you sleepy or any medicines mentioned below:

  • Any angiotensin converting enzyme (ACE) inhibitor, used to treat many conditions such as high blood pressure: Taking this with LYRICA may increase the chance for swelling and hives
  • Avandia (rosiglitazone), Avandamet (contains rosiglitazone and metformin), or Actos (pioglitazone) used for diabetes: Taking these with LYRICA may increase the chance of weight gain or swelling of your hands or feet
  • Any narcotic pain medicine (such as oxycodone), tranquilizers or medicines for anxiety (such as lorazepam): Taking these with LYRICA may increase the chance for dizziness and sleepiness

Ready to ask your doctor about LYRICA? Learn what information to give your doctor on the next page.

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LYRICA is not for everyone. LYRICA may cause serious, even life threatening, allergic reactions. Stop taking LYRICA and call your doctor right away if you have any signs of a serious allergic reaction. Some signs are swelling of your face, mouth, lips, gums, tongue, throat or neck or if you have any trouble breathing, or have a rash, hives or blisters.

Drugs used to treat seizures increase the risk of suicidal thoughts or behavior. LYRICA may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Patients, family members or caregivers should call the doctor right away if they notice suicidal thoughts or actions, thoughts of self harm, or any unusual changes in mood or behavior. These changes may include new or worsening depression, anxiety, restlessness, trouble sleeping, panic attacks, anger, irritability, agitation, aggression, dangerous impulses or violence, or extreme increases in activity or talking. If you have suicidal thoughts or actions, do not stop LYRICA without first talking to your doctor.

LYRICA may cause swelling of your hands, legs and feet, which can be serious for people with heart problems. LYRICA may cause dizziness and sleepiness. You should not drive or work with machines until you know how LYRICA affects you. Also, tell your doctor right away about muscle pain or problems along with feeling sick and feverish, or any changes in your eyesight including blurry vision or if you have any kidney problems or get dialysis.

Some of the most common side effects of LYRICA are dizziness, blurry vision, weight gain, sleepiness, trouble concentrating, swelling of your hands and feet, dry mouth, and feeling “high.” If you have diabetes, tell your doctor about any skin sores.

You may have a higher chance for swelling and hives if you are also taking angiotensin-converting enzyme (ACE) inhibitors so tell your doctor if you are taking these medications. You may have a higher chance of swelling of your hands or feet or gaining weight if you are also taking certain diabetes medicines. Do not drink alcohol while on LYRICA. You may have a higher chance for dizziness and sleepiness if you take LYRICA with alcohol, narcotic pain medicines, or medicines for anxiety.

Before you start LYRICA, tell your doctor if you are planning to father a child, or if you are pregnant, or plan to become pregnant. Breastfeeding is not recommended while taking LYRICA. If you have had a drug or alcohol problem, you may be more likely to misuse LYRICA.

In studies, a specific type of blood vessel tumor was seen in mice, but not in rats. The meaning of these findings in humans is not known.

Do not stop taking LYRICA without talking to your doctor. If you stop suddenly you may have headaches, nausea, diarrhea, trouble sleeping, increased sweating, or you may feel anxious. If you have epilepsy, you may have seizures more often.


LYRICA is indicated to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain and pain after shingles. LYRICA is also indicated to treat partial onset seizures in adults with epilepsy who take 1 or more drugs for seizures.

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